This paper have been supported by the Flow Cytometry Core Facility of

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New York, USA: Oxford University Press; 2007:62?16. 3. Horner MJ, Ries LAG, Krapcho M, Neyman N, Aminou R, Howlader N, Altekruse SF, Feuer EJ, Huang L, Mariotto A, et al: Surveillance, epidemiology, and finish benefits (SEER) program, SEER cancer PubMed ID: statistics review, 1975?006. Bethesda, MD: National Cancer Institute; 2008. Public-Use, 4. Xie P, Stunz LL, Larison KD, Yang B, Bishop GA: Tumor necrosis element receptor-associated issue 3 is a crucial regulator of B cell homeostasis in secondary lymphoid organs. Immunity 2007, 27:253?67. five. Gardam S, Sierro F, Basten A, Mackay F, Brink R: TRAF2 and TRAF3 signal adapters act cooperatively to manage the maturation and survival signals delivered to B cells by the BAFF receptor. Immunity 2008, 28:391?01. 6. Nagel I, Bug S, CS-7922 web Tonnies H, Ammerpohl O, Richter J, Vater I, Callet-Bauchu E, Calasanz MJ, Martinez-Climent JA, Bastard C, et al: Biallelic inactivation of TRAF3 in a subset of B-cell lymphomas with interstitial del(14) (q24.1q32.33). Leukemia 2009, 23:2153?155. 7. Keats JJ, Fonseca R, Chesi M, Schop R, Baker A, Chng WJ, Van Wier S, Tiedemann R, Shi CX, Sebag M, et al: Promiscuous mutations activate the noncanonical NF-kappaB pathway in many myeloma. Cancer Cell 2007, 12:131?44. eight. Annunziata CM, Davis RE, Demchenko Y, Bellamy W, Gabrea A, Zhan F, Lenz G, Hanamura I, Wright G, Xiao W, et al: Frequent engagement from the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in numerous myeloma. Cancer Cell 2007, 12:115?30. 9. Braggio E, Keats JJ, Leleu X, Van Wier S, Jimenez-Zepeda VH, Valdez R, Schop RF, Price-Troska T, Henderson K, Sacco A, et al: Identification of copy quantity abnormalities and inactivating mutations in two adverse regulators of nuclear factor-kappaB signaling pathways in Waldenstrom's macroglobulinemia. Cancer Res 2009, 69:3579?588. ten. Xie P, Kraus ZJ, Stunz LL, Bishop GA: Roles of TRAF molecules in B lymphocyte function. Cytokine Development Issue Rev 2008, 19:199?07. 11.This paper have been supported by the Flow Cytometry Core Facility from the Cancer Institute of New Jersey (P30CA072720). We would like to express our gratitude to Dr. P. Leif Bergsagel for his essential comments and stimulating discussions on this manuscript, and for supplying us the human PubMed ID: MM cell lines utilised within this study. We would also prefer to thank Anand Desai, Jacqueline Baron, Benjamin Kreider, Will Meng and Almin Lalani for technical help of this study.Edwards et al. BMC Cancer 2013, 13:481 19 ofAuthor details 1 Department of Cell Biology and Neuroscience, Rutgers University, 604 Allison Road, Nelson Labs Space B336, Piscataway, NJ 08854, USA. 2Graduate Plan in Molecular Biosciences, Rutgers University, Piscataway, NJ 08854, USA. 3Rutgers Cancer Institute of New Jersey, New Brunswick, USA. Received: 17 September 2013 Accepted: 11 October 2013 Published: 16 October 2013 References 1. Morton LM, Wang SS, Devesa SS, Hartge P, Weisenburger DD, Linet MS: Lymphoma incidence patterns by WHO subtype inside the United states, 1992?001. Blood 2006, 107:265?76. two.